Accession Number:

AD1099198

Title:

Active Cellular and Subcellular Targeting of Nanoparticles for Drug Delivery

Descriptive Note:

Journal Article - Open Access

Corporate Author:

NAVAL RESEARCH LAB WASHINGTON DC WASHINGTON United States

Personal Author(s):

• Nag,Okhil K.
• Delehanty,James B.

Report Date:

2019-10-18

Pagination or Media Count:

27.0

Abstract:

Nanoparticle NP-mediated drug delivery NMDD for active targeting of diseases is a primary goal of nanomedicine. NPs have much to offer in overcoming the limitations of traditional drug delivery approaches, including off-target drug toxicity and the need for the administration of repetitive doses. In the last decade, one of the main foci in NMDD has been the realization of NP-mediated drug formulations for active targeted delivery to diseased tissues, with an emphasis on cellular and subcellular targeting. Advances on this front have included the intricate design of targeted NP-drug constructs to navigate through biological barriers, overcome multidrug resistance MDR, decrease side effects, and improve overall drug efficacy. In this review, we survey advancements in NP-mediated drug targeting over the last five years, highlighting how various NP-drug constructs have been designed to achieve active targeted delivery and improved therapeutic outcomes for critical diseases including cancer, rheumatoid arthritis, and Alzheimers disease. We conclude with a survey of the current clinical trial landscape for active targeted NP-drug delivery and how we envision this field will progress in the near future.

Descriptors:

• nanoparticles
• nanomedicine
• nanobiotechnology
• organelles
• tumors
• cancer
• alzheimer disease
• diseases and disorders
• drug therapy
• cell physiological processes
• intracellular membranes

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE