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Novel Tumor Suppressor Gene in Hereditary X Linked Ovarian Cancers

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Technical Report,15 May 2018,14 May 2019

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Health Research, Inc. Buffalo United States

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Our previous work has identified an ovarian cancer risk locus on the X-chromosome and likely within the gene MAGEC3. The overall goal of this proposal is forward the idea that MAGEC3 is a tumor suppressor gene and to determine the scope and impact of the mechanism. Aim 1 is focused on studying the mechanism of MAGEC3 silencing in clinical samples. Aim 2 uses cell lines to study the function of MAGEC3 and Aim 3 will confirm our findings in mouse xenograft models. We determined that candidate tumor suppressor MAGEC3 is highly likely to be transiently expressed and cell cycle regulated with tight epigenetically-related expression of the protein increasing the confidence that it is a tumor suppressor gene. This result was achieved through the engineering of multiple cell lines with inducible MAGEC3 expression and transgene tags that will enable continuing RNA and protein level analyses. Single cell level expression analyses confirmed cell cycle association and flow cytometry protein-level analysis also supports these findings.

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  • Medicine and Medical Research
  • Medicine and Medical Research

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