Accession Number:

AD1098687

Title:

Integrin Regulation of Ferroptosis in Breast Cancer

Descriptive Note:

Technical Report,15 Jan 2017,14 Jul 2019

Corporate Author:

University of Massachusetts Medical School Worcester United States

Personal Author(s):

Report Date:

2019-11-01

Pagination or Media Count:

44.0

Abstract:

The hypothesis being tested in this proposal is that breast cancer cells, especially metastatic cells, are prone to rapid increases in ROS and lipid peroxidation caused by adverse micro-environmental conditions and that these oxidative bursts could have deleterious consequences including ferroptosis. Ferroptosis is defined as an iron-dependent, non-apoptotic form of programmed cell death characterized by the accumulation of intracellular soluble and lipid reactive oxygen species ROS.For this reason, breast tumor cells must acquire mechanisms to protect against oxidative bursts and ferroptosis to metastasize.

Subject Categories:

  • Medicine and Medical Research
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE