Accession Number:

AD1098671

Title:

The role of an aggrecan 32mer fragment in post-traumatic osteoarthritis

Descriptive Note:

Technical Report,30 Sep 2018,29 Sep 2019

Corporate Author:

The University of Melbourne VIC 3052 Australia

Personal Author(s):

• Fosang,Amanda
• Malfait,Anne-Marie
• Malfait,Anne-Marie

Report Date:

2019-10-01

Pagination or Media Count:

23.0

Abstract:

Recommended to be brief approx. 200 words of the main findings during the reporting period. In this fourth reporting period, we successfully developed an assay to measure the aggrecan 32mer fragment in human and mouse serum. The 32mer has great potential as a novel biomarker for OA pain, as well as a target marker for aggrecanase activity. We have applied for a one-year no cost extension to further develop the assay, testing cohorts of existing human and mouse sera. Specifically, we will validate the use of plasma 32mer levels as markers for osteoarthritis pain in mice at different time points after DMM surgery, and this in wildtype as well as Chloe mice as negative controls. In addition, we will continue to validate the assay in existing human sera.

Descriptors:

• immunotherapy
• immunomodulation
• pain
• arthritis
• cartilage
• surgery
• joints (anatomy)
• peptides
• histology
• culture techniques
• connective tissue cells
• biological markers

Subject Categories:

• Anatomy and Physiology
• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE