Accession Number:

AD1098512

Title:

Mesenchymal Stem Cell Control of Metastatic Prostate Cancer Cell Evolution and Therapy Resistance in the Bone Microenvironment

Descriptive Note:

Technical Report,15 Aug 2018,14 Aug 2019

Corporate Author:

H. Lee Moffitt Cancer Center and Research Institute Tampa United States

Personal Author(s):

• Lynch,Conor C.

Report Date:

2019-09-01

Pagination or Media Count:

7.0

Abstract:

The goal of this proposal is to examine the impact of interleukin-28 in promoting the resistance of prostate cancer cells in bone. In the first year of this award we have made significant progress in Aim 1 while Aim 2 and Aim 3 are underway. Resources for Aim 4 are currently being coordinated. Overall, we are on track with the stated milestonesobjectives.

Descriptors:

• prostate cancer
• bone diseases
• apoptosis
• resistance
• stem cells
• osteoblasts
• cancer research
• oncology
• metastasis

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE