Accession Number:

AD1096904

Title:

The Plateau Method for Forensic DNA SNP Mixture Deconvolution

Descriptive Note:

Journal Article - Open Access

Corporate Author:

MIT Lincoln Laboratory Lexington United States

Report Date:

2017-11-27

Pagination or Media Count:

9.0

Abstract:

Identification of individuals in complex DNA mixtures remains a challenge for forensic analysts. Recent advances in high throughput sequencing HTS are enabling analysis of DNA mixtures with expanded panels of Short Tandem Repeats STRs andor Single Nucleotide Polymorphisms SNPs. We present the plateau method for direct SNP DNA mixture deconvolution into sub-profiles based on differences in contributors DNA concentrations in the mixtures in the absence of matching reference profiles. The Plateau method can detect profiles of individuals whose contribution is as low as 1200 in a DNA mixture patent pending.

Subject Categories:

  • Biochemistry
  • Sociology and Law

Distribution Statement:

APPROVED FOR PUBLIC RELEASE