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Effect of Exertion on Adult Breathing Parameters: Literature Review and Meta-analysis

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Technical Report,01 Jun 2019,31 Mar 2020

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711 HPW/RHM Wright-Patterson AFB United States

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The inhalation route is of particular concern for exposure to hazardous chemicals in the workplace and an important pathway for environmental exposures in everyday life. Physiologically based pharmacokinetic PBPK models have been proposed as tools for computation of internal dosimetry for both aggregate risk and cumulative risk. Among the stressors that are known to have an impact on the absorption, distribution, and elimination of chemicals are heat and exercise stress. The impact of these stressors on parameters used to describe inhalation was evaluated via literature review and synthesis. Data from up to 13 groups of healthy adult subjects were used to derive linear or second order polynomial relationships between exertion or heart rate and pulmonary ventilation rate, tidal volume, and breathing frequency. These relationships will allow future application of PBPK modeling-based strategies to prioritize among various cumulative risk scenarios involving chemicals and the many other stressors present in the workplace and other environments.

Subject Categories:

  • Environmental Health and Safety
  • Anatomy and Physiology
  • Anatomy and Physiology

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