Experiments and Simulations on Short Chain Fatty Acid Production in a Colonic Bacterial Community
Journal Article - Open Access
MIT Lincoln Laboratory Lexington United States
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Understanding how production of specific metabolites by gut microbes is modulated by interactions with surrounding species and by environmental nutrient availability is an important open challenge in microbiome research. As part of this endeavor, this work explores interactions between F. prausnitzii, a major butyrate producer, and B. thetaiotaomicron, an acetate producer, under three different in vitro media conditions in monoculture and coculture. In silico Genome27scale dynamic flux balance analysis dFBA models of metabolism in the system using COMETS Computation of Microbial Ecosystems in Time and Space are also tested for explanatory, predictive and inferential power.