Examination of Neuroimaging, Cognitive Functioning, and Plasma Biomarkers in a Longitudinal Cohort: Fort Devens
Technical Report,30 Sep 2018,29 Sep 2019
Boston VA Research Institute Boston United States
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This study aims to conduct follow-up longitudinal cognitive evaluations on a sub-sample of 100 Time 3 Ft. Devens Cohort veterans, most of whom were last evaluated in-person for cognitive functioning and with neuroimaging in the mid-1990s, to compare objective measurement of reported decline and to determine cross-sectional blood and neuroimaging biomarkers blood and structural volumetrics will also include longitudinal analyses at 25 years post deployment to the Gulf region, that may be consistent with cognitive outcomes and presumed pathobiological mechanisms oxidative stress, ROS of GWI. These data will evaluate the utility of previously unavailable blood and neuroimaging markers of oxidative stress, to devise a new diagnostic test for GWI in subgroups of GW veterans TBI and OP exposed, and to provide a potential objective biomarker of treatment efficacy in clinical trials.
- Medicine and Medical Research
- Stress Physiology