Accession Number:

AD1096564

Title:

Examination of Neuroimaging, Cognitive Functioning, and Plasma Biomarkers in a Longitudinal Cohort: Fort Devens

Descriptive Note:

Technical Report,30 Sep 2018,29 Sep 2019

Corporate Author:

Boston VA Research Institute Boston United States

Personal Author(s):

Report Date:

2019-10-01

Pagination or Media Count:

10.0

Abstract:

This study aims to conduct follow-up longitudinal cognitive evaluations on a sub-sample of 100 Time 3 Ft. Devens Cohort veterans, most of whom were last evaluated in-person for cognitive functioning and with neuroimaging in the mid-1990s, to compare objective measurement of reported decline and to determine cross-sectional blood and neuroimaging biomarkers blood and structural volumetrics will also include longitudinal analyses at 25 years post deployment to the Gulf region, that may be consistent with cognitive outcomes and presumed pathobiological mechanisms oxidative stress, ROS of GWI. These data will evaluate the utility of previously unavailable blood and neuroimaging markers of oxidative stress, to devise a new diagnostic test for GWI in subgroups of GW veterans TBI and OP exposed, and to provide a potential objective biomarker of treatment efficacy in clinical trials.

Subject Categories:

  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE