Urinary Biomarkers of Tuberculosis: Potential for Diagnosis and Beyond
Technical Report,01 Jun 2018,31 May 2019
Joan and Sanford I.Weill Medical College New York United States
Pagination or Media Count:
Tuberculosis TB remains the leading cause of deaths due to an infectious disease. A major barrier to control of the pandemic is the lack of rapid, point-of-care biomarkers. Urinary biomarkers were identified that can both diagnose active TB and decrease or increase, over time, while on anti-TB treatment. The objective of this proposal is to determine the reliability of these as urinary biomarkers, both for diagnosis and assessment of treatment of TB. To do this we have obtained urine samples from two distinct clinical cohorts. The first cohort consists of 37 participants with active pulmonary TB followed over time. We have successfully completed metabolomic analysis of urine samples from this cohort and have identified several urinary metabolites that decrease with treatment response and are associated with mycobacterial burden. The second cohort consists of 100 participants with active pulmonary TB, 100 participants who have latent TB and 100 uninfected controls. We have completed metabolomic analysis for 100 randomized urine samples from this cohort and will complete metabolomic analysis for the additional 200 in the next month. Follow on statistical studies should be completed in the next 1-2 months.
- Medicine and Medical Research
- Genetic Engineering and Molecular Biology