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Elucidating the Role of Joint Disuse in the Development of Osteoarthritis Following Return to High-Impact Loading

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Technical Report,30 Sep 2017,29 Sep 2018

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University of Connecticut Farmington United States

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The studies completed within the last six months added the experimental components of joint loadings imparted through direct external impact or joint instability via ACL transection which also causes increased shear loading on articular surfaces. Recent experiments using animals at the proposed 20 week old age point revealed a lack of response to joint unloading of the articular cartilage tidemark interface of uncalcified and calcified cartilage. Joint unloading via hindlimb suspension is known to activate the tidemark within articular cartilage as well as ligament entheses, a proposed hallmark of disuse in this study. This lack of response in our joint disuse model for 2 weeks of joint unloading may be related to how the histological studies were designed. Recent human clinical data using superimposition of PET and MRI data indicates that earliest abnormalities that precede articular cartilage pathology is mineralization activity in the perichondrial surfaces and the enthesis. Because our sectioning was sagittal through the condyles, most of these regions were not examined. Using the remaining tissue blocks from the experimental animals, frontal sections that include the femur and tibial will be analyzed using the cryohistological workflow.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology

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