Accession Number:

AD1096097

Title:

Role of Tgf Beta and Wnt Signaling in Liver Tissue Homeostasis, Tumorigenesis, and Cancer

Descriptive Note:

Technical Report,01 Jul 2017,30 Jun 2019

Corporate Author:

Leland Stanford Junior University Stanford United States

Personal Author(s):

• Sarkar,Abby
• Nusse,Roeland
• Jin,Yinhua
• Wu,Peng
• Rulifson,Eric

Report Date:

2019-10-01

Pagination or Media Count:

10.0

Abstract:

During the funding period, we have generated a number of novel mouse models and genome editing tools to identify the cellular origins of liver cancer. These new tools have helped identify genes involved in regulating liver tumorigenesis. Thus, we have made progress towards advancing basic knowledge on the origin of liver cancer.

Descriptors:

• biology
• cell division
• diseases and disorders
• rna sequence analysis
• therapy
• epithelial cells
• biomedical research
• cancer
• developmental biology
• homeostasis
• transcription factors
• cell physiological processes
• liver diseases
• neoplasms
• stem cells

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE