Characterizing Myeloid Cell Activation in NF1 Vasculopathy
Technical Report,01 Jul 2015,31 Dec 2018
Augusta University Augusta United States
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Our original proposal seeks to understand the mechanisms underlying macrophage recruitment and activation in NF1-related vasculopathy. We have developed two mouse models that closely recapitulate NF1-related arterial stenosis and aortic aneurysm formation and propose to examine the contribution of MCP-1CCR2 signaling and redox biology to these pathologies. As aneurysm and arterial stenosis represent two ends of a continuum, perturbations in macrophage recruitment and redox biology may underlie both pathologies therefore, we have attempted to take a broad approach to both models in regards to these mechanisms. We have completed all proposed experiments, which have been described in several high-impact publications with multiple manuscripts undergoing Editorial Review for publication.
- Medicine and Medical Research