Accession Number:

AD1096040

Title:

Characterizing Myeloid Cell Activation in NF1 Vasculopathy

Descriptive Note:

Technical Report,01 Jul 2015,31 Dec 2018

Corporate Author:

Augusta University Augusta United States

Personal Author(s):

Report Date:

2019-03-01

Pagination or Media Count:

131.0

Abstract:

Our original proposal seeks to understand the mechanisms underlying macrophage recruitment and activation in NF1-related vasculopathy. We have developed two mouse models that closely recapitulate NF1-related arterial stenosis and aortic aneurysm formation and propose to examine the contribution of MCP-1CCR2 signaling and redox biology to these pathologies. As aneurysm and arterial stenosis represent two ends of a continuum, perturbations in macrophage recruitment and redox biology may underlie both pathologies therefore, we have attempted to take a broad approach to both models in regards to these mechanisms. We have completed all proposed experiments, which have been described in several high-impact publications with multiple manuscripts undergoing Editorial Review for publication.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE