Pulsed Electromagnetic Field Therapy for Accelerating Peripheral Nerve Regeneration and Preserving Neuromuscular Junctions
Technical Report,15 Aug 2017,14 Aug 2018
Wake Forest University Health Sciences Winston-Salem United States
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Major accomplishments include receipt of IACUC and ACURO approvals for all animal protocols, receipt and installation of a PEMF cage system providing commercially available PEMF waveforms, and initiation of experiments in Specific Aims 1 and 2. The PEMF cage system is installed in a dedicated room in the Wake Forest vivarium. Caging does not interfere with the PEMF waveform. Eight rats were placed on study to address Specific Aims 1 and 2. Initial gait analysis was performed, the sciatic nerve was transected and repaired, and the animals received PEMF treatment for four months. Animals will have functional testing utilizing EMG and muscle force generation the first week in November 2018. A second cohort of 8 rats will be trained and initiated on the project the week of November 12, 2018. A second PEMF system constructed by the Wake Forest Center for Nanotechnology and Molecular Materials will be installed in the dedicated vivarium room in November 2018 and will permit simultaneous running of sham-PEMF exposure rats.
- Medicine and Medical Research
- Anatomy and Physiology