Toward a Molecular Understanding of Noise Induced Hearing Loss
Technical Report,30 Sep 2017,29 Sep 2018
University of Maryland School of Medicine Baltimore United States
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The purpose of this project is to generate the cell type-specific molecular blueprint of changes in gene expression following different types of noise exposure and their treatments, in the inner ear. To this end, we have a Established the hair cell HC and supporting SC cell-specific translatome of adult mouse inner ears b Established the molecular changes induced by PTS-resulting noise exposure in HC, SC and whole inner ears, 6 and 24 hours after noise exposure and began the TTS analysis c We identified critical differences in the response of male and female mice to noise, and obtained approval to modify Specific Aim 3to focus on the response to Heat Shock profiling male and female mice, separately.
- Anatomy and Physiology