Accession Number:



Toxicology Assessment for Department of Defense Strategic Environmental Research and Development Program (SERDP) Project WP 2601: Sustainable Environmentally Green Polyurethanes for Erosion-Resistant Coatings

Descriptive Note:

Technical Report,01 Mar 2016,30 Jun 2018

Corporate Author:

Army Public Health Center Aberdeen Proving Ground United States

Personal Author(s):

Report Date:


Pagination or Media Count:



This Toxicology Assessment was conducted in accordance with ASTM Guideline E-2552. Compounds evaluated are part of an effort to develop non-isocyanate-based polyurethane coatings for protection of erosion-prone components of military equipment and aircraft, such as helicopter rotor blades. Eight perfluorinated compounds were evaluated. In most cases, experimental data were not available, so predictions were made using Quantitative Structure-Activity QSAR models. In common with other perfluorinated compounds, many of these compounds are predicted to be developmental or reproductive toxicants, and to be recalcitrant in the environment. Compounds structurally similar to bisphenol A are at least potential endocrine disruptors. The two most favorable compounds are 2-difluoroiodomethyl-2,3,3-trifluorooxirane and 2,2,3,3,4,4,5,5-octafluorohexane-1,6-diamine. In vitro experimental testing is recommended.

Subject Categories:

  • Coatings, Colorants and Finishes

Distribution Statement: