Targeting Neuromimicry in Prostate Cancer Metastasis
Technical Report,07 Dec 2017,06 Dec 2018
Washington State University Pullman United States
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The purpose of this project is to investigate the functional and mechanistic roles of a neural enzyme monoamine oxidase A MAOA and its downstream neuronal effectors in mediating prostate cancer-nerve reciprocal interactions and prostate cancer metastasis. Throughout the Year 2 of this study, we demonstrated that MAOA promotes perineural invasion of prostate cancer cells in 3D prostate cancer-nerve cell co-cultures and that MAOA inhibitor clorgyline suppresses prostate cancer cell perineural invasion in vitro. By analyzing orthotopic xenograft tumor samples generated from the Year-1 study, we also showed that MAOA promotes tumor cell proliferation and nerve density, which could be inhibited by the MAOA inhibitor clorgyline, in xenograft tumors.
- Anatomy and Physiology
- Medicine and Medical Research