Accession Number:

AD1095937

Title:

Targeting Neuromimicry in Prostate Cancer Metastasis

Descriptive Note:

Technical Report,07 Dec 2017,06 Dec 2018

Corporate Author:

Washington State University Pullman United States

Personal Author(s):

Report Date:

2019-01-01

Pagination or Media Count:

11.0

Abstract:

The purpose of this project is to investigate the functional and mechanistic roles of a neural enzyme monoamine oxidase A MAOA and its downstream neuronal effectors in mediating prostate cancer-nerve reciprocal interactions and prostate cancer metastasis. Throughout the Year 2 of this study, we demonstrated that MAOA promotes perineural invasion of prostate cancer cells in 3D prostate cancer-nerve cell co-cultures and that MAOA inhibitor clorgyline suppresses prostate cancer cell perineural invasion in vitro. By analyzing orthotopic xenograft tumor samples generated from the Year-1 study, we also showed that MAOA promotes tumor cell proliferation and nerve density, which could be inhibited by the MAOA inhibitor clorgyline, in xenograft tumors.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE