Mismatch Repair Loss Renders ER+/HER2- Breast Cancer Susceptible to HER2/3 Inhibition
Technical Report,01 Mar 2018,28 Feb 2019
Sanford Burnham Prebys Medical Discovery Institute La Jolla United States
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The objective of this proposed study is to investigate a role for HER23 activation in MutLdefective ER breast cancer progression and resistance to endocrine therapy. By targeting HER23 signaling and key nodes of adaptive kinome response, we aim to significantly improve patient disease-specific survival.
- Medicine and Medical Research