Accession Number:

AD1095864

Title:

Mismatch Repair Loss Renders ER+/HER2- Breast Cancer Susceptible to HER2/3 Inhibition

Descriptive Note:

Technical Report,01 Mar 2018,28 Feb 2019

Corporate Author:

Sanford Burnham Prebys Medical Discovery Institute La Jolla United States

Personal Author(s):

Report Date:

2019-03-01

Pagination or Media Count:

12.0

Abstract:

The objective of this proposed study is to investigate a role for HER23 activation in MutLdefective ER breast cancer progression and resistance to endocrine therapy. By targeting HER23 signaling and key nodes of adaptive kinome response, we aim to significantly improve patient disease-specific survival.

Subject Categories:

  • Medicine and Medical Research
  • Biochemistry
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE