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Spinal Cord Swelling and Alterations in Hydrostatic Pressure After Acute Injury

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Technical Report,30 Sep 2014,29 Sep 2018

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University of British Columbia, ICORD Vancouver Canada

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In YEAR 4 we completed the statistical analysis of the existing duraplasty data as part of AIM 3 and are currently finalizing a manuscript on the role of duraplasty in a porcine model of SCI and its effects on intraparenchymal hemodynamics,metabolism, histological and behavioral recovery. Furthermore, as part of AIM 4, we evaluated the pressure inside the injured spinal cord the spinal cord pressure, or SCP and outside the injured spinal cord within the intrathecal space the intraspinal pressure or ISP using our pig model of SCI. We furthermore evaluate how their relationship to one another evolve with time over the first week post-injury, and how they may be influenced by location within the spinal cord relative to the site of injury. Lastly, we evaluated if CSF pressure, cord pressure, and spinal cord blood flow was associated with impairment or preservation of PRx.

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