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Novel Strategies to Improve Immunomodulation and Noninvasive Clinical Monitoring in VCA

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Technical Report,15 Jul 2018,14 Jul 2019

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Brigham and Womens Hospital Boston, United States

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Safely minimizing the risks associated with vascularized composite allotransplantation VCA is crucial for functional restoration of wounded warriors. Our overarching goal is enabling functional and aesthetic restoration to patients with severe, unreconstructable vascularized composite tissue defects by safe VCA protocols with minimal side effects. Our specific aimsare 1 Establishing the efficacy of a low-dose IL-2 protocol at enabling minimization of immunosuppression to sirolimus monotherapy in recipients of VCA. 2 Exploring correlations between cellular and molecular immunoassays performed in specimens from VCA recipients and their donors with clinical observations of stability and rejection. In future trials, these assays can be developed into tools that prospectively predict rejection and tolerance in VCA, and 3 Implementing next-generation methods to supplement and potentially overcome limitations of established methods such as histology and ultrasound biomicroscopy UBM. We are enrolling 5 subjects for VCA. Less than 3 months after VCA, once recipient and allograft are stable, we will administer an IL-2 based protocol intended to enable minimization of immunosuppression to sirolimus monotherapy. Afterwards, immunosuppression will be weaned.

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  • Medicine and Medical Research

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