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Blood Biomarker Profile of TBI-Associated Cognitive Impairment Among Old and Young Veterans

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Technical Report,30 Sep 2017,29 Sep 2018

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Northern California Institute for Research and Education San Francisco United States

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The goal of this project is to define the biomarker profile of TBI-associated cognitive impairment TBI-CI in veterans and compare it to that of veterans with TBI with no CI TBI, veterans with no TBI and CI no TBI-CI,and to age-matched controls. Our overall hypothesis is that TBI-associated CI involves a unique biomarker profile that has features distinguishable from CI without TBI and normal aging. Examining biomarkers in exosomes from the central nervous system, we found multiple blood-based biomarkers that differed significantly between the four groups.This study will refine our understanding of the underlying mechanisms in TBI-associated CI, help predict who is at greatest risk of developing CI in veterans with TBI, and identify who may benefit from interventions and treatment for CI and its prevention.

Subject Categories:

  • Medicine and Medical Research
  • Biology
  • Biochemistry

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