Accession Number:

AD1095505

Title:

Blood Biomarker Profile of TBI-Associated Cognitive Impairment Among Old and Young Veterans

Descriptive Note:

Technical Report,30 Sep 2017,29 Sep 2018

Corporate Author:

Northern California Institute for Research and Education San Francisco United States

Personal Author(s):

Report Date:

2018-10-29

Pagination or Media Count:

12.0

Abstract:

The goal of this project is to define the biomarker profile of TBI-associated cognitive impairment TBI-CI in veterans and compare it to that of veterans with TBI with no CI TBI, veterans with no TBI and CI no TBI-CI,and to age-matched controls. Our overall hypothesis is that TBI-associated CI involves a unique biomarker profile that has features distinguishable from CI without TBI and normal aging. Examining biomarkers in exosomes from the central nervous system, we found multiple blood-based biomarkers that differed significantly between the four groups.This study will refine our understanding of the underlying mechanisms in TBI-associated CI, help predict who is at greatest risk of developing CI in veterans with TBI, and identify who may benefit from interventions and treatment for CI and its prevention.

Subject Categories:

  • Medicine and Medical Research
  • Biology
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE