Blood Biomarker Profile of TBI-Associated Cognitive Impairment Among Old and Young Veterans
Technical Report,30 Sep 2017,29 Sep 2018
Northern California Institute for Research and Education San Francisco United States
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The goal of this project is to define the biomarker profile of TBI-associated cognitive impairment TBI-CI in veterans and compare it to that of veterans with TBI with no CI TBI, veterans with no TBI and CI no TBI-CI,and to age-matched controls. Our overall hypothesis is that TBI-associated CI involves a unique biomarker profile that has features distinguishable from CI without TBI and normal aging. Examining biomarkers in exosomes from the central nervous system, we found multiple blood-based biomarkers that differed significantly between the four groups.This study will refine our understanding of the underlying mechanisms in TBI-associated CI, help predict who is at greatest risk of developing CI in veterans with TBI, and identify who may benefit from interventions and treatment for CI and its prevention.
- Medicine and Medical Research