Accession Number:

AD1095498

Title:

Objective Assessment of Auditory Pathway Integrity and Functional Hearing Abilities

Descriptive Note:

Technical Report,01 Aug 2018,31 Jul 2019

Corporate Author:

The Geneva Foundation Tacoma United States

Personal Author(s):

Report Date:

2019-08-01

Pagination or Media Count:

16.0

Abstract:

In preparation for imminent hair cell regeneration clinical trials, it is essential to develop a systematic approach to assess the degree of functional hearing restoration as the regeneration of hair cells, the reintegration of these cells and their associated neural pathways within the auditory system, and the reorganization of the auditory cortex to newly restored sound inputs progresses over time. Therefore, the purpose of developing a functional assessment battery is to provide multiple opportunitiesto demonstrate success, from early physical reintegration of the cochlea through the thalamus-cortical pathway such as tests of outer and inner hair cell, brainstem, and efferent system activity, to simple and more complex sound discrimination crucial for understanding speech in noisy environments. To demonstrate the utility of this functional assessment battery, listeners with a wide range of hearing loss from normal hearing to moderate-to-severe hearing loss will evaluated to establish expected values for different degrees of hearing damage. To validate the repeatability of the functional assessment battery, a subset of listeners with varying degrees of hearing loss will be tested on multiple occasions. Finally, the extent to which simple and complex pre-attentive discrimination abilities, as well as cochlear reintegration measures, can predict complex speech in noise performance will be evaluated.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE