Accession Number:

AD1095438

Title:

Frontoparietal Priority Maps as Biomarkers for mTBI

Descriptive Note:

Technical Report,30 Sep 2014,29 Sep 2018

Corporate Author:

University of Minnesota Minneapolis United States

Personal Author(s):

Report Date:

2018-12-01

Pagination or Media Count:

9.0

Abstract:

This project involves a series of behavioral and magnetic resonance imaging MRI experiments that will determine the degree to which difficulties with visual attention, saccade targeting and motion perception associated with mild traumatic brain injury mTBI can be attributed to damaged cortical brain networks serving attention and eye movement planning. The hypothesis being tested is that spatial attention and eye movement deficits associated with mTBI result from disruption of the gray matter andor the white matter in cortical networks that control attention allocation and eye movements. A combination of functional MRI and diffusion-weighted imaging will allow us to measure 1 integrity in cortical networks in frontal and parietal brain regions responsible for attention allocation and eye-movement planning, 2 integrity in the white matter carries outputs from these regions to the sub-cortical nuclei that control eye movements, and 3 correlation between these biomarkers and behavioral measures of visual performance in veterans who have and have not experienced mTBI. At the time of writing, preliminary analyses have been completed on all data collected during the study a single final manuscript is in preparation.

Subject Categories:

  • Medicine and Medical Research
  • Weapons Effects (Biological)
  • Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE