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Prostate Cancer Grade Mapping with Transrectal Electrical Impedance Tomography

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Technical Report,15 Sep 2017,14 Sep 2018

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Trustees Of Dartmouth College Hanover United States

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The primary objective of this research is to combine advanced integrated electronics with transrectal electrical impedance tomography TREIT and electrical impedance sensing biopsy EIS-Bx devices to improve TRUS-guided prostate biopsy procedures and help to address the challenge of distinguishing aggressive from indolent disease in men newly diagnosed with prostate cancer. The novelty in this program falls into two categories 1 we aim to couple our single point EIS-Bx measurement device with an array of electrodes adhered to a standard end-fired TRUS probe Halters team and 2 we aim to develop a custom application specific integrated circuit ASIC that will enable us to measure these electrical properties over a wide frequency range optimal for discriminating high from low-grade prostate cancer and at high frame rates required for real-time prostate biopsy procedures Odames team. During the third year of this program we have continued to 1 optimize and validate our initial ASIC device and small form-factor EIT system, 2 optimize finite element method meshing approaches and reconstruction algorithms for imaging the electrical properties of prostate during an TREIT EIS-Bx procedure, 3conducted phantom and ex vivo animal tissue studies in preparation for ex vivo prostate studies, and 4 completed submission and received approval for human subjects testing. Over the next year, our plans are to primarily focus on conducting the ex vivo prostate study, while continuing to optimize the hardware and image reconstruction algorithms.

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  • Medicine and Medical Research

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