Adult Tissue-Derived Stem Cells and Tolerance Induction in Nonhuman Primates for Vascularized Composite Allograft Transplantation
Technical Report,30 Sep 2016,29 Sep 2019
Uniformed Services University of the Health Sciences (USUHS) Bethesda United States
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Amputations and unsalvageable injuries with devastating tissue loss are common in the combat wounded. Reconstructive transplantation in the civilian setting using vascular composite allotransplants VCA composed of multiple tissues skin, muscle, nerve, bone in combination with long-term multidrug immunosuppression has been encouraging. However, the success of hand and face vascularized composite allografts VCA depends on high levels of immunosuppressive medications. The ability to minimize the high risks of both rejection episodes and immunosuppressive medications could allow for safer and more widespread VCA application to wounded service members.
- Medicine and Medical Research