Microtubule-Based Therapy for Neurodegeneration in Gulf War Illness: Studies with hiPSC-Derived Neurons from Gulf War Veterans
Technical Report,30 Sep 2018,29 Sep 2019
Drexel University Philadelphia United States
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We have generated a bank of human induced pluripotent stem cells hiPSCs from the blood of Gulf War veterans some with and some without Gulf War Illness, and we have conducted research on rat and human neurons on the microtubule-based mechanisms underlying neuronal deficits in GWI, thus enabling us to move forward on microtubule-based therapies. Toward the goal of rushing effective drug therapies to the sufferers of GWI, we propose to utilize the hiPSCs in rapid-throughput analyses of microtubule-active drugs that are either already FDA-approved or in advanced clinical trials.
- Medicine and Medical Research