Targeted Alteration of Dietary Omega-3 and Omega-6 Fatty Acids for the Treatment of Post-Traumatic Headaches
Technical Report,30 Sep 2018,29 Sep 2019
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Bethesda United States
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Post-traumatic headache PTH is a common problem in military personnel due to their high rate of traumatic brain injury TBI. From a prior study in migraine we demonstrated that a high Omega-3low Omega-6 H3-L6 diet intervention reduced headache pain, altered circulating anti- and pro-nociceptive lipid mediators and their precursor fatty acids, reduced psychological distress and improved quality-of-life in a chronic headache population. We propose to carry out a 2-arm, parallel group, randomized, controlled 12-week dietary intervention trial to evaluate the biochemical effects and therapeutic efficacy of two dietary interventions one high in Omega-3 and the other high in Omega-6, reflecting the usual US diet in patients with PTH that are migrainous. We hypothesize that compared to the Control Diet high Omega-6, low Omega-3, the H3-L6 intervention will produce significant increases in anti-nociceptive n-3 metabolites including 17-hydroxy DHA Primary Biochemical Aim, and reductions in pro-nociceptive n-6 metabolites. Further, we hypothesize that compared to the Control Diet, the H3-L6 intervention will produce significant improvement in the Headache Impact Test-a headache-specific quality of life measure-Primary Clinical Outcome, mean total Headache Hours per day, and mean Severe Headache Hours per day.
- Medicine and Medical Research
- Food, Food Service and Nutrition