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Identification of Prostate Cancer Predisposition Genes on the Y Chromosome

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Technical Report,21 Sep 2015,20 Sep 2019

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University of Utah Salt Lake City United States

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We hypothesize the existence of Y chromosome genesvariants related to increased risk, and propose multiple genetic analyses to efficiently identify the responsible genes or variants. We used a unique genealogical resource and a novel study design to identify men carrying Y chromosomes exhibiting high- and low-risk of prostate cancer. We sequenced the Y chromosome to identify rare variants associated with risk, and validated candidate variants in additional high- and low-risk Y chromosome carriers. Analysis of the 10 high risk Y sequence data compared to the 10 low risk data identified a set of 3 coding and 3 non-coding candidate variants seen in excess in high-risk Y chromosomes and not observed in the low risk set We selected 100 Utah Y chromosomes for complete Y chromosome sequencing as cases and acquired Y chromosome sequence data for 1,800 control men. Data fur the 100 additional samples was used to statistically test the 6 candidate variants identified in the initial set of 10 high risk cases and 10 controls there were no significant results. We also used the high-risk YID cases sequence data to identify 3 additional candidate variants observed in excess in high-risk Y chromosomes these 3 candidates were tested with a taqman assay in an additional 150 high risk YID samples and 650 low to normal prostate risk YID samples. No significant results were found

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  • Medicine and Medical Research

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