Does Venous Thrombosis Chemoprophylaxis (VTC) Adversely Affect the Hemorrhagic Lesion in a Preclinical Model of Penetrating Traumatic Brain Injury
Technical Report,30 Sep 2018,29 Sep 2019
Walter Reed Army Institute of Research and Naval Medical Research Center Silver Spring United States
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Severe penetrating traumatic brain injury TBI patients represent the highest risk for complication associated with thromboembolism formation and hematoma expansion. Previous clinical studies demonstrated that the early use of VTC in these patients did not exacerbate intracerebral hematoma while reducing the risk of thromboembolism. Despite these findings, there is no consensus among neurosurgeons regarding its use in the presence of TBI, the appropriate timing or the dosing regimen. To address these issues, we propose to investigate the safety of VTC with regard to adversely affecting intracerebral hemorrhage in a rat model of penetrating TBI. The results of this study will potentially provide the scientific basis for modifying the clinical practice guidelines regarding the use of heparinoids for severe TBI in both civilian and military populations.
- Anatomy and Physiology
- Medicine and Medical Research