Identification of Novel Genetic Causes of Lung Cancer by Sequencing the Germline Exome of Never Smoker Young Lung Cancer Patients
Technical Report,30 Sep 2018,29 Sep 2019
Childrens Hospital Boston United States
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Treatment efficacy and survival in cancer has been constantly improving over the past several decades for children and for adults over forty years of age. For the young adult population, however, no progress has been made. Identification of genetic factors contributing to the development of cancer may help to identify individuals at high risk and thus provide rational strategy for prevention and through understanding the underlying biology it can also help to devise novel therapeutic strategies. We will sequence the germline DNA of lung cancer patients that are under 35 years of age, who never smoked and had no apparent exposure to toxic chemicals. In such a population, genetic factors will play a more prominent role than in an older population more affected by environmental factors, therefore, those genetic factors could be identified more easily.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research