Leveraging the Framingham Study to Investigate Relationships Between Traumatic Brain Injury, Military Service, Alzheimer's Disease and Related Dementias
Technical Report,01 Aug 2018,31 Aug 2019
Boston University Medical Center Boston United States
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A large body of evidence suggests that people experiencing a single or repetitive TBI in civilian and military settings may have an increased risk of late-life cognitive decline or neurodegenerative disease, including Alzheimers disease AD and AD-related dementias ADRD. But the specific clinical features and neuropathological substrates of TBI-associated dementia, as well as the mechanisms underlying this apparent association, are less clear. This project leverages the extensive existing resources of the Framingham Heart Study FHS, which includes access to a long-committed community-based study sample, as well as health, lifestyle, biomarker, genetic, cognitive, neuroimaging and neuropathological data. We are combining these existing resources with new self-report TBI and military service data. This study will comprehensively characterize the role of TBI and military service on key ADADRD outcomes, and identify genetic and non-genetic factors that modify these relationships.
- Medicine and Medical Research
- Anatomy and Physiology