Human Leukocyte Antigen in Gulf War Veterans: Association with Symptoms and Inflammatory Markers
Technical Report,30 Sep 2018,29 Sep 2019
University of Minnesota Minneapolis United States
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GWI has affected a large number of veterans who served during the 1990-1991 Persian Gulf War. Despite extensive study, the pathogenesis and pathophysiology remain unclear. There is evidence of genetic effects and blood biomarkers that point to disruptions in immune system function as one underlying cause of GWI symptoms however, studies evaluating immune system involvement in GWI have typically included small, non-representative samples. This project aims to evaluate GWI symptoms, genes associated with immune system functioning, and biomarkers of immune system dysfunction, inflammation, and autoimmunity in a large sample of Gulf War veterans with and without GWI to elucidate the relation of GWI to immune system dysfunction. If our hypothesis that GWI reflects immune system dysfunction resulting from genetic susceptibility coupled with environmental exposures is supported, this will open new avenues of potential treatment, consistent with the burgeoning field of immunogenetics.
- Medicine and Medical Research