Examination of Plasma PON1 Paraoxonase Activity and Genotype in Gulf War Veterans
Technical Report,30 Sep 2018,29 Sep 2019
Northern California Institute for Research and Education San Francisco United States
Pagination or Media Count:
The goal of this project is to evaluate the extent to which PON1192Gulf War GW-related exposure interactions contribute to the risk for Gulf War Illness GWI, as defined by the Centers for Disease Control and PreventionCDC and Kansas case definitions in a large sample of GW veterans. Specifically, we will 1 determine the associations between GWI and GW-related exposures with the potential for cholinergic effects e.g., persona pesticide use, exposure to OP nerve agents in subgroups of veterans with different PON1192 genotype. 2determine the associations between GWI and each GW-related cholinergic exposure in subgroups of veterans with different PON1 activity levels and 3 calculate prevalence odds ratios for GWIexposure associations separately for sugbroups of veterans with different PON1192 genotypes and PON1 activity levels.
- Medicine and Medical Research