A Closed-Loop Neural Prosthesis for Restoration of Function After Traumatic Brain Injury
Technical Report,01 Sep 2017,31 Aug 2018
Case Western Reserve University Cleveland, United States
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Significant progress has been made in developing activity-dependent stimulation ADS microdevices for use in both rodent and non-human primate NHP models of traumatic brain injury TBI. Specifically, microdevices have been successfully assembled, benchtop tested for functionality, and deployed in a rodent model of TBI to determine the optimal time window for delivery of the therapy. Our preliminary results from a completed cohort of rodents indicate that we can delay ADS treatment for 1, 2 or 3 weeks after injury and still observe improvement in motor performance. Moreover, the functionality and versatility of software for the NHP microdevices has been successfully upgraded by adding several new features such as stimulus rate monitoring. In parallel, the design of the substrates for the head-mounted rigid flexibleand backpack all-rigid portions of the NHP microdevice has been greatly advanced.
- Anatomy and Physiology