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An Association of Unique microRNA Turnover Machinery with Prostate Cancer Progression

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Technical Report,15 Sep 2018,14 Sep 2019

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University of Texas Southwestern Medical Center Dallas United States

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Prostate cancer PCa is the second highest cancer mortality among male cancer in USA. This disease is still incurablebecause PCa once becomes metastatic and develops drug resistance when cancer cells undergo epithelial-to-mesenchymaltransition EMT and acquire cancer stem cell CSC phenotypes. Emerging evidence has shown that the presence ofmetastatic PCa is associated with CSC phenotype that is likely associated with its resistance to radiation or chemotherapy.The preliminary data from this study clearly demonstrate that several tumor suppressor microRNAs miRNAs involved inregulating these processes are often degraded by IFIT5. Also, elevated IFIT5 is associated with PCa malignancy. Thus, thisstudy will delineate the mechanism of IFIT5 in tumor suppressor miRNA degradation, and examine IFIT5 gene regulation. Bydetermining its clinical correlation, this study will provide valuable biomarkers for lethality of PCa, which will an immediateimpact on patient prognosis and selection for more suitable agent. The outcome of this study will provide a betterunderstanding of miRNAs biogenesis associated with aggressive PCa exhibiting CSC phenotypes. Most importantly, the longtermthe impact of this study will generate more effective therapeutic strategy of CRPC.

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  • Medicine and Medical Research

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