Damp-Mediated Innate Immune Failure and Pneumonia After Trauma
Technical Report,30 Sep 2018,29 Sep 2019
Beth Israel Deaconess Medical Center Boston United States
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Injury resulting from combat trauma dramatically impacts the host immune response. Combat wounds release Damage Associated Molecular Patterns DAMPs and importantly infection of the host is more common after injury. This program studies how DAMPs alter the immune response to trauma through the study of specific patient populations, highly correlative animal models, computational modeling and statistics and molecular mechanisms of action, all focused toward identifying therapeutic targets. We have assembled a group of laboratories that have each previously studied individual DAMPs and their impact on innate immunity. Project 1 studies mitochondrial formyl peptides and DNA. Project 2 studies heme and its gasotransmitter product, carbon monoxide. Project 3 studies extracellular purinergic signaling. Project 4 studies the alveolar physicochemical environment. Project 5 studies oligonucleotides and global immune phenotypic alterations by injury. Project 6 studies the roles of complement and reactive oxygen species and computational modeling.
- Anatomy and Physiology