Molecular and Cellular Determinants of Malignant Transformation in Pulmonary Premalignancy
Technical Report,01 Jul 2016,30 Jun 2019
University of California, Los Angeles Los Angeles United States
Pagination or Media Count:
During the no-cost extension period we partially completed the Major Task 3. To evaluate the differences in immune landscapes between premalignancy and cancer, the tumor and premalignant microenvironments were assessed for CD3, CD4, CD8, CD11c, CD68, HLA-DR, TIM3, LAG3, Granzyme B, FOXP3, PD-1, PD-L1, Ki67 and cytokeratin expression utilizing multiplex immunofluorescence MIF staining. Thus, we significantly expanded the originally proposed immune marker panel, which will allow us to define the infiltrating immune cell landscapes with much higher resolution. The MIF data analysis is ongoing and will be completed utilizing other funding mechanisms.
- Medicine and Medical Research