Accession Number:

AD1095175

Title:

Molecular and Cellular Determinants of Malignant Transformation in Pulmonary Premalignancy

Descriptive Note:

Technical Report,01 Jul 2016,30 Jun 2019

Corporate Author:

University of California, Los Angeles Los Angeles United States

Personal Author(s):

Report Date:

2019-10-01

Pagination or Media Count:

19.0

Abstract:

During the no-cost extension period we partially completed the Major Task 3. To evaluate the differences in immune landscapes between premalignancy and cancer, the tumor and premalignant microenvironments were assessed for CD3, CD4, CD8, CD11c, CD68, HLA-DR, TIM3, LAG3, Granzyme B, FOXP3, PD-1, PD-L1, Ki67 and cytokeratin expression utilizing multiplex immunofluorescence MIF staining. Thus, we significantly expanded the originally proposed immune marker panel, which will allow us to define the infiltrating immune cell landscapes with much higher resolution. The MIF data analysis is ongoing and will be completed utilizing other funding mechanisms.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE