Accession Number:

AD1095171

Title:

Elastomeric Auxetic Urogential Meshes: Exploring Alternatives to Knitted Polypropylene

Descriptive Note:

Technical Report,30 Sep 2016,29 Sep 2019

Corporate Author:

Magee-Womens Research Institute and Foundation Pittsburgh United States

Report Date:

2020-01-01

Pagination or Media Count:

31.0

Abstract:

We developed novel synthetic prolapse meshes based on auxetic pore geometries ie the pores expand rather than contract when loadedmanufactured from soft elastomers polydimethysiloxane, PDMS, and polycarbonate urethane, PCU. This is contrary to current polypropylene meshes in which the pores collapse with loading and they are manufactured from stiff polypropylene. The purpose of this study was to test the hypothesis that the novel elastomeric, auxetic prolapse meshes will evoke improved tissue integration and preserve vaginal function relative to current commonly used polypropylene prolapse meshes. To test this hypothesis, we developed and validated a rabbit model for implanting mesh onto the internal vagina of a rabbit via a lumbar colpopexy. Furthermore, we were able to reproduce one of the most common mesh complications - a mesh exposure corroborating the utility of the rabbit as a model for understanding mesh complications. Following implantation for 3 months onto the rabbit vagina, the PDMS mesh had the least negative impact on the vagina. The PCU mesh impacted the rabbit vagina similar to Restorelle. Collectively, these results suggest that the host response to mesh is more sensitive to the polymer and further optimization of the design of the mesh is warranted. The results of this study were used as preliminary data in an NIH R01 application which was successfully funded in February 2019 NICHD R01HD097187. Additionally, the results of this study were published in two peer-reviewed manuscripts a third manuscript is in preparation and discussed in over 20 scientific local and national meetingsseminarsconferences.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE