Accession Number:

AD1095167

Title:

Stroma-Based Prognosticators Incorporating Differences between African and European Americans

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2019

Corporate Author:

University of California Irvine United States

Report Date:

2019-12-01

Pagination or Media Count:

19.0

Abstract:

Our objective was to use standard Formalin-fixed Paraffin-embedded FFPE tissue to identify RNAs in prostate tumor-adjacent stroma that distinguish between cancers in European Americans EA and African Americans AA, and to determine which fraction of these differences were associated with DNA methylation andor protein changes. Gleason Score, chemical relapse status, and approximate age, were used to match AA with EA patients. We found striking differences in interferon stimulated genes between AA and EA tumor-adjacent stroma, of potential value as prognostic and therapeutic targets. To establish an in vitro test-bed for these observations, it became necessary to developed a valuable resource of new normal and cancer-associated fibroblast cell cultures. The advances made in this project are the basis of a funded five year follow-up grant.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE