High Spatiotemporal Resolution Prostate MRI
Technical Report,15 Aug 2015,14 Aug 2018
Mayo Clinic Rochester United States
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Prostate cancer PCa is the second leading cause of cancer death in men. However, when detected and treated promptly the five-year relative survival rate approaches 100 percent. The overall purpose of this project is to develop improved means using MRI for detecting prostate cancer with the potential for differentiating disease aggressiveness. The hypothesis is that dynamic whole-volume contrast-enhanced perfusion imaging of the prostate gland can be performed with 1 mm isotropic spatial resolution and 2 sec frame times, providing an order of magnitude improvement over current techniques. The specific aims are i to develop an MRI acquisition technique for time-resolved 3D MRI of the prostate, ii to develop a fundamentally new coil element family having variable sensitivity along the superior-to inferior direction, iii to incorporate partial Fourier and acceleration methods into high speed reconstruction to provide high quality 3D images in real time at frame times of 2 sec or less.
- Anatomy and Physiology
- Medicine and Medical Research