Optimizing Hemodynamic Support of Acute Spinal Cord Injury Based on Injury Mechanism
Technical Report,30 Sep 2014,29 Sep 2018
University of British Columbia Vancouver Canada
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This grant is focused on the augmentation of MAP with vasopressors and determining how such MAP augmentation would best be implemented during compression, after decompression, or both. In YEAR 2 of this grant we finalized the comparison of two commonly used vasopressors, norepinephrine NE and phenylephrine PE after SCI. As our data suggested NE would better maintain elevated MAPs, using NE, in YEAR 3 we studied our first animal surgeries as part of Aim 1-3 to determine the impact of MAP augmentation during compression andor decompression, on tissue hemodynamics within the spinal cord after a traumatic SCI. In YEAR 4, we finalized a draft manuscript on the role of vasopressor support in SCI. Furthermore, in YEAR 4 we sent human and pig CSF and serum sample to UofA for metabolomic and lipidomic profiling as part of TASK 3 of AIM 2 and 3. Although, conclusive results on the lipidomicsmetabolomics work was not available prior to this report, we are committed to completing the analysis within the next few months the microdialysis samples have been collected and sent to Dr. Li we just await the actual mass spectrometry analysis.
- Medicine and Medical Research