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A Systems Biology Approach to Radiation Biodosimetry and the Host-Environment Interaction: Applications to Mass Casualty Triage in the Polytrauma Patient

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Technical Report,15 Apr 2018,14 Apr 2019

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US Army Institute of Surgical Research JBSA Fort Sam Houston United States

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We are using a rodent model, of radiation and thermal injury to examine existing and novel biomarkers of radiation exposure alone and combination injuries radiation plus thermal at varying levels in hair, skin, blood, and major organs. The emphasis is on pan-omic work, be we also are implementing histopathology and IHC to elucidate relationships between biomarker change and potential clinical impacts in samples collected. A focus is on identification of candidate markers that are obtained least invasively i.e., blood or hair and therefore can be applied readily to the field for rapid assessment of military and civilian populations that have potential exposure. Many of the single injury animal exposures have been completed for both burn and radiation only exposures, with the majority of animals exposed completing a 14 day time course. The highest radiation only exposure group however only survives until day 7, therefore this group does not complete the full proposed time course. Many of the combination injury animal exposures have also been completed. We have observed a clear combinatorial effect on mortality however, and have adjusted our experimental groups accordingly to end the time courses following 20 percent burn injury and radiation exposure by Day 2 in these combination groups in order to ensure viable sample collection. All samples generated to date and preserved for subsequent molecular analysis have been transferred to USACEHR.

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