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Biomarkers of Spontaneous Recovery from Traumatic Spinal Cord Injury

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Technical Report,30 Sep 2018,29 Sep 2019

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Feinstein Institute for Medical Research Manhsset United States

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Immediately after a traumatic spinal cord injury SCI, a person confronts 3 major questions 1how much function have they lost, 2 what treatments promote recovery, and 3 how much physical recovery can they expect over time To answer the first question, a clinical exam tests motor and sensory function throughout the body. The second question is still largely unanswered standard rehabilitation focuses on maximizing preserved function and managing medical complications of living with SCI. Currently, there is no FDA-approved drug to promote recovery after SCI. The third question is also unanswered there is no standardized model to predict functional recovery, which occurs mostly within the first year after SCI. Surprisingly little is known about the biological processes influencing recovery after SCI. Experiments indicate that inflammation worsens the initial area of damage and inhibits physical recovery. Signs of inflammation occur in people newly injured and in people living with SCI for many years. Our hypothesis is that some inflammatory factors are higher in individuals with SCI that achieve less physical recovery. To test this hypothesis, we are performing a multi-site prospective, longitudinal study to measure circulating biochemical responses and functional recovery throughout the 1st year after SCI, within the same individuals. Data will be collected at least once within 0-3 days post injury dpi, and then at 3, 6, and 12 months after SCI. The goal is to use these data to build an easy-to-implement, predictive multi-scale model of functional recovery after SCI that incorporates biomarkers related to inflammation. This project is in its forth year. To date, we have screened 751 participants and enrolled 36 participants by recruiting across 6 different institutions.

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  • Medicine and Medical Research

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