Accession Number:

AD1095096

Title:

A SOF Damage Control Resuscitation Cocktail

Descriptive Note:

Technical Report,15 Apr 2014,14 Apr 2016

Corporate Author:

University of Washington Seattle United States

Personal Author(s):

Report Date:

2016-07-01

Pagination or Media Count:

32.0

Abstract:

Objective The goal of this project is to develop a new damage control resuscitation DCR cocktail made of fibrinogen, Hextend, Vasopressin, and tranexamic acid for use by SOFs that is capable of improving survival from polytrauma in austere settings. These components were tested in a swine polytrauma model of hemorrhagic shock with traumatic brain injury free internal bleeding from an aortic tear, and femur fracture treated using tactical combat casualty care TCCC over 6 hours. Results Fibrinogen concentrate decreased internal blood loss and enabled 3 animals to survive to 6 hours while also enhancing brain and vital organ blood flow. There was no effect of TXA in this model. In conclusion, our cocktail consisting of Hextend, Vasopressin, and fibrinogen concentrate decreased blood loss and enabled survival to 6 hours in an otherwise lethal swine polytrauma model.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE