The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy
Technical Report,08 Sep 2014,28 Feb 2019
Wake Forest University Winston Salem United States
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The purpose of this study is to identify the mechanisms whereby the bone marrow microenvironment is involved in the regulation of tumor dormancy. Aim1 will identify and explore how disseminated tumor cells DTCs stay dormant for long periods of time. We postulate that DTCs drive the bone marrow niche into dormancy. Aim2 will determine how DTCs escape dormancy, consequently rendering them more susceptible to the chemotherapy. During this period, we found that a slow-growing prostate cancer PCa may contribute to the maintenance of osteoblastic niche dormancy in vitro. In addition, we observed that a fast-growing osteoblast may have ability to induce bone metastatic PCa growth, and that a fast-growing osteoblast may enhance susceptibility of bone metastatic PCa to chemotherapy.
- Medicine and Medical Research