Monitoring Neurocognitive Performance and Electrophysiological Activity after Mild Traumatic Brain Injury
Technical Report,01 Mar 2013,30 Sep 2017
Huntington Medical Research Pasadena United States
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Our project aimed to explore a wide variety of objective approaches to identify acute concussion mTBI patients and distinguish them from trauma controls that did not suffer head injury. Neuropsychometry, balance, actigraphy, electroencephalography EEG, event related potentials ERPs, magnetoencephalography MEG, magnetic resonance imagining and spectroscopy MRI and MRS, and blood biomarkers were evaluated. EEG, MEG, MRI, MRS, blood metalloproteinase-9, and blood fatty acid lipolysis all differed in mTBI, especially1-5 days after injury, and also differently at 30 days after injury. Preliminary analyses indicate the combination of techniques are even more informative than they are individually, especially combinations of EEG with blood lipids, MMP9, and MRI volumetrics and spectroscopy. The data suggest that further testing of these new objective EEG and blood biomarkers have the greatest potential for widespread utility.
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