Prevention of Breast Cancer Skeletal Metastases with Parathyroid Hormone
Technical Report,01 Feb 2018,31 Jan 2019
Stanford University Stanford United States
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During this research period we have demonstrated that parathyroid hormone PTH started at the same time as intramammary implantation of murine 4T1-BGL breast cancer cells can decrease metastases to the skeleton but not to lung, liver or spleen. This is associated with changes in expression of metastasis genes in bone. We have further demonstrated that 4 weeks of PTH can decrease engraftment and growth of murine or human breast cancer cells injected into the intratibial bone marrow cavity. In preliminary studies we have demonstrated that knockdown of the PTH receptor PTH1R in 4T1 breast cancer cells abrogates the effect of PTH on reducing bone metastases, as does removal of PTH1R signaling in osteoblasts.
- Medicine and Medical Research