Evaluation of Clinically Relevant Prognostic Indicators in a Model of Mild TBI/Concussion
Technical Report,30 Sep 2017,29 Sep 2018
Geneva Foundation Tacoma United States
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Closed head concussions, also known as mild traumatic brain injuries mTBIs, are of great concern to both military and civilian populations alike. While acute concussion symptoms resolve for most patients, a subset will experience effects that persist chronically. Emphasis has been placed upon identifying prognostic indicators to distinguish these vulnerable patient populations for the purpose of providing enhanced care. Two potential clinically-relevant prognostic indicators include altered brain glucose metabolism as detected by FDG-PET imaging and changes in serum microRNA levels. The aim of this work is to comprehensively characterize longitudinal profiles of these two potential prognostic indicators following single and repeated injuries in a rodent model of closed head concussion. These studies utilize the WRAIR Projectile Concussive Impact PCI model, which is a military relevant model of closed head concussion developed under the directive of the Combat Care Casualty Research Program CCCRP. In this Year 2 Report, we provide finalized results to characterize longitudinal alterations in brain glucose uptake and associated neurobehavioral changes through 6 months following single or repeated closed head concussions. In addition, altered microRNAs following a single concussion are identified through 14 days following injury.
- Medicine and Medical Research