Early Detection of Clinically Significant Prostate Cancer Using Ultrasonic Acoustic Radiation Force Impulse (ARFI) Imaging
Technical Report,15 Sep 2017,14 Sep 2018
Duke University Durham United States
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Prostate cancer PCa is the second most common cancer in men in the United States, with over 220,000 cases newly diagnosed, and over 27,000 deaths annually. Although diagnosis is currently performed by biopsy under ultrasound guidance, the systematic sampling approach has poor sensitivity due in large part to the low specificity of B-mode ultrasound for PCa. Our overall goal is to develop a 3D ultrasound acoustic radiation force impulse 3D-ARFI elasticity imaging system that can be used in the clinic for first-time biopsy to facilitate targeting prostate biopsies toward regions that are suspicious for clinically significant PCa due to their elevated stiffness. In the past year, we have finalized our sequencing, data acquisition, and real-time processing and 3D display algorithms. We have analyzed our imaging system in tissue mimicking phantoms, and obtained IRB approval for and initiated imaging in patients with prostate cancer who are expecting radical prostatectomy. We have also developed data analysis tools to be used to assess the system performance in the in vivo studies. The impact of this system, if successful, will be to change the standard of care by enabling detection of the most significant disease present in the prostate upon initial biopsy and diagnosis, facilitating improved treatment decisions and patient outcomes.
- Medicine and Medical Research