Neuromodulation and Neurorehabilitation for Treatment of Functional Deficits after mTBI plus PTSD
Technical Report,30 Sep 2018,29 Sep 2019
Chicago Association for Research and Education Hines United States
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It is estimated that 12-16 of veterans suffer a mild traumatic brain injury mTBI during deployment. This can result in persistent symptoms causing persistent disability. Moreover, incidence of post-traumatic stress disorder PTSD is increased among veterans with mTBI. Unfortunately there are few to no treatments that induce or accelerate functional recovery after mTBI. This study will determine i the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training APT when combined with intermittent theta burst stimulation iTBS, a type of repetitive transcranial magnetic stimulation TMS and ii determine how APT iTBS changes the neurocognitive system of attention in individuals with persistent attention deficits related to mTBI and PTSD. Previous studies have shown that iTBS can produce alterations in cerebral function that facilitate learning and recovery from neurologic injury. Specific Aim I will determine immediate effects of Active APT-III Active iTBS on neuropsychological measures of attention, measures of function and symptoms between baseline and endpoint. Aim II will determine sustainability and long-term of effects of Active APT III Active iTBS for neuropsychological, symptom and functional outcome measures, by comparing endpoint and 10-week post-treatment follow up.Aim III will determine how effects identified for Aims 1 and 2 relate to the underlying neurocognitive system of attention by examining the relationship between the functional and structural connectivity of the attention networks with the neuropsychological, functional and symptoms outcomes. Aim IV addresses the need to confirm safety of iTBS in this population.